June 20, 2024

The dark side of exosome therapy

Reading Time: <1 minuteExosome drip is a hot topic in aesthetic medicine.At many beauty clinics, you'll see advertisements that list the highest quality, safest, effective against cancer, effective for rejuvenation, and other wonderful effects. Even on You Tube, you can see many doctors promoting the effectiveness of exosome infusion without disclosing any risks. There is no clear definition of exosome therapy. There is no evidence either. It is also not a drug approved by the Ministry of Health, Labor and Welfare. It's also not standardized. No clinical trials with a high level of evidence, such as double-blind trials, have been conducted. There is also no standardization or administration protocol for exosome preparations. There are many companies that sell exosomes, and they promote themselves by saying that their quality is the best. There are various origins such as deciduous dental pulp, fat cells, umbilical cord, and placenta. Recently, intravenous injections of exosomes have been administered to top athletes to help them recover from damage caused by competition.You Tube videos and press releases about the continuous administration of exosomes have been promoting the athlete in a big way. Isn't this considered doping? In conclusion, I think that intravenous administration of reagents that are not approved under the Pharmaceutical and Medical Devices Act to improve physical performance can be considered an act of doping. It's out according to NPB standards, and it's out even under the standards proposed by JBC. Intravenous administration of less than 100 ml within 12 hours is not doping, but continuous intravenous administration of unapproved reagents to improve physical performance is ethically and common sense as a doctor's no-no before doping. At this point, we believe that exosome therapy that prioritizes profit and uses athletes as promotional materials is a problem. The JBC states: ``Boxers participating in matches held under the jurisdiction of the JBC must not ingest or apply to their body any narcotic, drug, or drug that enhances or diminishes their performance in the ring. ”(https://www.jbc.or.jp/info/jbc_rulebook_excerpt.pdf2 https://www.jbc.or.jp/rls/2021/0520.pdf 3 https://boxingnews.jp/news/83424/ https://www.sponichi.co.jp/battle/news/2021/05/19/kiji/20210519s00021000415000c.html etc. is proposed. https://npb.jp/anti-doping/foryourdailylife_1.html Section M2.2 of the World Anti-Doping Agency (WADA) Prohibited List states: ``Intravenous infusions and/or intravenous injections exceeding a total of 12 mL per 100 hours are prohibited. ``This excludes cases where it is legitimately received in each process of clinical testing.'' The NPB Medical Committee considers those that meet the following two points to be "legitimately received intravenous infusions."
  1. There is a medical record by the doctor, which clearly states the diagnosis name, basis of diagnosis, drug name, amount used, and method of use.
  2. This is a treatment using a drug approved under the Pharmaceutical Affairs Law, and is used within an indication.
Even if they are not prohibited doping substances, injections and infusions that are not legitimately received during medical examinations (including all procedures during emergency transport, surgery, outpatient treatment, and hospitalization) or during clinical examinations are anti-doping drugs.・It would be a violation of the doping regulations. In any case, he can say that exosome infusion and intravenous administration should not be carried out, as the protocol and reagents to use are completely unknown at this point. If you are an athlete, please be careful not to fall into the trap of using exosome drips.    

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