Anti-aging with metformin

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The number of inquiries regarding metformin has increased.

 Metformin is a proven drug that has been used to treat diabetes for over 1990 years.In the United States, it was approved by the FDA in the XNUMXs, and its efficacy and safety have been reviewed in Japan, making it the first-line drug for the treatment of diabetes.

 It is known that "there are many research reports on the therapeutic effect of metformin in the past, and it has a preventive effect by suppressing the onset of diabetes in the diabetic reserve group."

 A research team in the United States conducted a "Metformin Aging Control" (TAME) study at 15 medical institutions in the United States. A survey of 70 elderly people aged 80 to 3,000 years was divided into a group that took metformin and a group that did not take metformin, and was followed up for 5 to 7 years.
Investigate the difference in lifespan, heart disease such as myocardial infarction, cancer, and dementia.

Do diabetics treated with metformin have longevity?

Research report that metformin extends lifespan
 A U.S. researcher said, "I expect metformin to have an anti-aging effect that extends healthy life expectancy. I think it may have an anti-aging effect not only for diabetics but also for healthy people." Report too.

 A large UK study, UKPDS, found that metformin reduced arteriosclerosis and reduced the risk of developing cardiovascular disease in patients with type 2 diabetes compared to other treatments. Studies have shown that mice treated with metformin have a 5% longer lifespan than mice not treated with metformin, and mice treated with metformin have reduced calorie intake, lower cholesterol levels, kidney disease and cancer. Onset is reduced.

It has also been reported that diabetics in their 70s who received metformin had a 15% reduction in mortality compared to non-diabetics.

 Studies have shown that metformin has a cancer-preventing effect.
Diabetics are at increased risk of developing cancer due to weakened immunity, insulin and insulin-like growth factors promote the development of some cancers, and people with type 2 diabetes have high blood insulin levels prior to diagnosis. This is because the condition often lasts for a long time.

 Metformin suppresses insulin production and may suppress cancer growth.It is also thought to have an antioxidant effect that prevents the increase of active oxygen.

 The characteristics of metformin are that it suppresses gluconeogenesis, promotes the utilization of sugar in the periphery such as muscles, and suppresses glucose absorption from the intestinal tract, so that it can be expected to have a hypoglycemic effect.
Recent studies have confirmed that metformin excretes sugar into the intestine.
You may also expect a diet effect.

 The mechanism of action of metformin has only recently been elucidated, and it has become clear that it activates an enzyme called AMP kinase.

 Lactic acidosis is a serious side effect of metformin.I also learned this risk as a serious side effect of metformin when I was a student in medical school, but in reality it is assumed to occur when many factors such as liver damage, decreased renal function, etc. are combined in the elderly. It seems that there is no problem for healthy people due to side effects.

In the 1990s, the efficacy of metformin was reviewed worldwide, and large-scale clinical trials using metformin were conducted in Europe and the United States, and it became clear that the frequency of metformin lactic acidosis is low.

I am neither diabetic nor a reserve force, but I have been taking metformin for over XNUMX years.
Please feel free to contact us if you have any patients who wish to take metformin.

 

Dr. Nir Barzilai on the TAME Study (Alliance for Aging Research 2015 year 4 month 28 day)
Study shows type 2 diabetics can live longer than people without the disease (University of Cardiff 2014 year 8 month 8 day)