Regenerative medicine outpatient

About regenerative medicine outpatient

Skin rejuvenation and skin regeneration

In our hospital, as regenerative medicine (stem cell cytokine therapy), treatment of sequelae of stroke, dementia, and intractable diseases such as cerebral infarction and cerebral hemorrhage.

Even now, when medical science has advanced, sequelae after cerebral hemorrhage and cerebral infarction are generally in the situation where there is no effective treatment and the recovery depends only on rehabilitation such as physical therapy.
Currently, there are no drugs or treatments that are effective in treating dementia, and only suppress the progression of symptoms caused by various drugs.

Cranial nerve cells are considered to be unrenewable after 6 months after the onset, and treatment of aftereffects after cerebral infarction in the chronic phase is performed only for the maintenance of residual functions by physical therapy such as rehabilitation at any medical institution. There is no active treatment intended.
In recent years, it has been found that brain nerve cells also regenerate due to advances in regenerative medicine.
Regenerative medicine is a treatment method that regenerates or reconstructs destroyed tissues by using cells and regenerative ability of the self. It is also expected to improve the pathological conditions that were previously impossible. (Effects vary between individuals)

From deciduous dental pulp
Cytokine cocktail
(Stem cell culture supernatant)
What is therapy?

Skin rejuvenation and skin regeneration
After cerebral infarction
Reduction of sequelae,

Cytokine cocktail therapy is a regenerative medicine that uses a culture supernatant of deciduous dental pulp stem cells, and has been reported to reduce sequelae after cerebral infarction. In consideration of safety issues, we are using a cytokine cocktail.

Sapporo Medical University reports cases where patients who had difficulty walking due to paralysis due to spinal cord injury improved their symptoms by administration of autologous stem cells and became able to walk independently in several weeks. .

However, when stem cell transplantation treatment is performed, the number of adult stem cells is small, so in order to achieve a certain level of effect, it is necessary to increase the number of stem cells by culturing them. However, there are reports of the possibility of cells becoming tumorous (cancerous) due to changes in the gene level during this culture process, and safety issues have been pointed out.

In subsequent studies, the effects of stem cell transplantation treatment were actually negligible because the administered stem cells themselves contributed to the repair of the damage, and most of the cytokines (growth factors) released from the administered stem cells were self-administered. Of stem cells received and found to repair the damage.

Nagoya University has reported that using cytokines responsible for the command lineage of each tissue actually released from stem cells has the same effect as stem cell transplantation treatment. In addition, it has been reported from Nagoya University that cytokines released from dental pulp-derived stem cells have been shown to have an effect on cerebral neurons, and that the aftereffects of cerebral infarction have improved.

* At present, unfortunately, there has not been a report showing complete effects on brain dysfunction after cerebral infarction, but only a report on motor paralysis (motor disorder).

Protocols such as dosage, administration period, and subject of administration have not been established yet, and the treatment is not fully established.

It has been found that the culture medium used to cultivate stem cells usually contains cytokines that are several hundred times higher than adults. There are reports that it is highly effective and does not cause inflammation compared to the adipose stem cell-derived supernatant.

This culture medium rich in cytokines is called cytokine cocktail (stem cell culture supernatant).

Cytokines don't have to worry about becoming tumorous (cancerous).In addition, pulp-derived cytokine cocktail therapy is attracting attention as a regenerative medicine that is safer and easier than stem cell transplantation and can be expected to achieve the same level of therapeutic effect.

Indication symptoms

  • Skin aging
  • paralysis
  • Motor dysfunction
  • Impaired vision
  • Dysphagia
  • Aphasia disorder
  • dementia
  • Motor dysfunction in the chronic phase after cerebral infarction
  • Peripheral nerve palsy

Indication disease

  • Glaucoma
  • Optic nerve atrophy
  • Auditory neuropathy
  • Brain dysfunction due to traffic injury
  • allergic rhinitis
  • Diabetic neurosis
  • Alzheimer's dementia
  • Amyotrophic lateral sclerosis (ALS)
  • Parkinson's disease
  • Various neurodegenerative diseases

Regenerative medicine skin treatment

Deciduous dental pulp stem cell supernatant
Inject subcutaneously into skin

Treatment timeAbout 10 minutes
Indication symptomsWrinkle improvement, skin tension, texture improvement, dullness improvement, acne scars, etc.
Treatment methodDirect injection or introduction with microneedles.
downtimePlease refrain from makeup only on the day.
painThere is almost no pain because the anesthetic of the coating is used.
Treatment effect manifestationIt will be felt from the next day.

Cytokines suppress skin aging and promote youthful skin regeneration.
This is a new treatment that can be performed in a short time without side effects.

Unlike conventional PRP therapy, there is an advantage that autologous blood collection is unnecessary and it can be performed quickly and easily.

Deciduous dental pulp stem cells and
Features of cytokine cocktail

Directly into the brain through the nose
The supernatant is absorbed,
It works.

Cytokine cocktail treatment is a regenerative treatment that promotes self-repair by activating stem cells in the brain by administering growth factors (cytokines).

Intranasal administration is a method in which a high concentration of drug is delivered to the brain in a shorter time than internal use or infusion by the route from the olfactory bulb to the interstitial region through the cell stroma, the route from the trigeminal nerve to the brain stem and spinal cord, and the capillaries in the mucous membrane. Reach inside.

Nasal administration
(1) Pathway from the olfactory bulb through the cell stroma to the brain intervening part
(2) Pathway from the trigeminal nerve to the brain stem and spinal cord
(3) Capillaries in the mucous membrane
As a result, a higher concentration of cytokines reaches the brain in a shorter time than internal use or infusion.

Treatment timeA few seconds (10 to 15 minutes on your back)
Number of treatments1-10 times 1 cool every 2 weeks for basic treatment.
Side effectsNone
Pain after treatmentReport does not.
Treatment effect manifestationEven if you can feel it from the next day though there are individual differences


1 weekly intervals, then
Nose and nose every 2 weeks
Perform an infusion.

Instillation and infusion of deciduous dental pulp derived cytokine cocktail (stem cell culture supernatant) using cytokine (protein) released from stem cells.

This treatment, which uses cytokines responsible for the command lineage of each tissue, is expected to have the same therapeutic effect as stem cell transplantation treatment. Alone, the administration method is the nasal nose that allows the fastest drug transfer to the brain. Infusion is used as a combined treatment.


Only the first medical examination fee10,000 yen(Tax not included)
No re-examination fee is required
Deciduous pulp stem cell supernatant
Nasal treatment
100,000 yen(Tax not included)
(Including the cost of high concentration hydrogen inhalation therapy)
Deciduous pulp stem cell supernatant
Nasal treatment 6 times
540,000 yen(Tax not included)
Deciduous pulp stem cell supernatant
Nasal treatment 10 times
800,000 yen(Tax not included)
Dental skin stem cell supernatant injection120,000 yen(Tax not included)
Deciduous pulp stem cell supernatant
IV treatment
120,000 yen(Tax not included)
(It becomes the content ingredient which added deciduous pulp stem cell supernatant to cocktail drip)
Deciduous pulp stem cell supernatant
Microneedle skin treatment
150,000 yen(Tax not included)


The main cells used in stem cell therapy are those collected from dental pulp, bone marrow, umbilical cord blood, placenta, fat, etc. Until now, the supernatant of adipocyte-derived stem cells has been widely used. .
Previously, we used adipose stem cell-derived supernatant for treatment.

We have used adipocytes-derived supernatant and cytokines for hair growth and hair growth treatment such as HARG therapy. In fat, adipocytes after liposuction are mostly used, and the risk of infectious diseases is not 100% denied, as with other biologics, and may cause an inflammatory response.
On the other hand, for dental pulp stem cells, donors and collection routes have been established and are superior to stem cells from other tissues in terms of safety, effectiveness, and anti-inflammatory effects.

PRP therapy is a plasma containing high-concentration platelets obtained by centrifuging collected blood, not a treatment that injects cytokines. Therefore, unlike stem cell therapy, it contains almost no growth factors or cytokines, and its cell activation effect is limited to some diseases such as sports.

In this hospital, combination therapy is also carried out, and a great therapeutic effect is obtained in the sports field and the beauty field.

This is the only medical institution in Japan that can receive combined treatment of PRP therapy and stem cell supernatant, and provides treatment for sports trauma of many world-renowned top athletes.

PRP therapy requires blood collection and requires time and effort.

Stem cell transplantation can cause inflammation and allergic reactions due to the proteins contained in the body, and the risk of side effects such as fever and fatigue.
On the other hand, treatment with stem cell culture supernatant is safe because it contains many growth factors and cytokines, and is expected to be as effective as stem cell transplantation.

The difference is whether you use cells or cytokines, which are therapeutic essences released from the cells.

It is an epoch-making treatment that can be done quickly and easily without burden on the body. Any method of administration is possible. (Introduction to the skin using eye drops, nose drops, drip, microneedle, fractional laser)

This is a next-generation treatment that solves the problems of regenerative treatment risks, complexity, and high costs.

Stem cell therapy
1: There is a risk of tumor
2: Takes a long time
3: Uncertain therapeutic effect due to culture method
4: Expensive treatment costs
5: Safety issues such as pulmonary embolism
6: In principle, no nasal treatment is performed
Stem cell culture supernatant
1: No tumor formation
2: Treatment is completed in a short time
3: Stable formulation and stable effect
4: Cheap treatment costs compared to stem cell treatment
5: High safety
6: Can be treated with nasal nose, direct approach to the brain

Counseling reservation
Free email consultation

Our hospital is fully booked to protect your privacy as much as possible. Please make a reservation by phone and come to the hospital. If you have any questions, please contact us by email.

Sakae Clinic Photo

Cosmetic dermatology and cosmetic surgery in Nagoya

Sakae Clinic

Nishiki, Naka-ku, Nagoya, Aichi Prefecture 3-5-21
Nishiki HOTEI Building 2F
Closed day: Wednesday, irregular holidays
10: 00: 19: 00

1 minute walk from Hisaya-Odori Station on Subway Sakuradori Line / Meijo Line
4-minute walk from Sakae Station on the Higashiyama Line