table of contents
- Skin rejuvenation, beautiful skin regeneration 肌
- What is deciduous dental pulp-derived cytokine cocktail (stem cell culture supernatant) therapy?
- Regenerative medicine skin treatment
- Characteristics of deciduous dental pulp stem cells and cytokine cocktail
- Introduction of the clinic
- Contact Us
- Article information
Skin rejuvenation, beautiful skin regeneration 肌
Skin rejuvenation and skin regeneration
In this hospital, we carry out treatment of skin aging care and beautiful skin regeneration as regenerative medicine (stem cell cytokine therapy).
Even now, when medical science has advanced, sequelae after cerebral hemorrhage and cerebral infarction are generally in the situation where there is no effective treatment and the recovery depends only on rehabilitation such as physical therapy.
Currently, there are no drugs or treatments that are effective in treating dementia, and only suppress the progression of symptoms caused by various drugs.
Cranial nerve cells are considered to be unrenewable after 6 months after the onset, and treatment of aftereffects after cerebral infarction in the chronic phase is performed only for the maintenance of residual functions by physical therapy such as rehabilitation at any medical institution. There is no active treatment intended.
In recent years, it has been found that brain nerve cells also regenerate due to advances in regenerative medicine.
Regenerative medicine is a treatment method that regenerates or reconstructs destroyed tissues by using cells and regenerative ability of the self. It is also expected to improve the pathological conditions that were previously impossible. (Effects vary between individuals)
From deciduous dental pulp
(Stem cell culture supernatant)
What is therapy?
Cytokine cocktail therapy is a regenerative medicine that uses a culture supernatant of deciduous dental pulp stem cells, and has been reported to reduce sequelae after cerebral infarction. In consideration of safety issues, we are using a cytokine cocktail.
Sapporo Medical University reports cases where patients who had difficulty walking due to paralysis due to spinal cord injury improved their symptoms by administration of autologous stem cells and became able to walk independently in several weeks. .
However, when stem cell transplantation treatment is performed, the number of adult stem cells is small, so in order to achieve a certain level of effect, it is necessary to increase the number of stem cells by culturing them. However, there are reports of the possibility of cells becoming tumorous (cancerous) due to changes in the gene level during this culture process, and safety issues have been pointed out.
In subsequent studies, the effects of stem cell transplantation treatment were actually negligible because the administered stem cells themselves contributed to the repair of the damage, and most of the cytokines (growth factors) released from the administered stem cells were self-administered. Of stem cells received and found to repair the damage.
Nagoya University has reported that using cytokines responsible for the command lineage of each tissue actually released from stem cells has the same effect as stem cell transplantation treatment. In addition, it has been reported from Nagoya University that cytokines released from dental pulp-derived stem cells have been shown to have an effect on cerebral neurons, and that the aftereffects of cerebral infarction have improved.
* At present, unfortunately, there has not been a report showing complete effects on brain dysfunction after cerebral infarction, but only a report on motor paralysis (motor disorder).
Protocols such as dosage, administration period, and subject of administration have not been established yet, and the treatment is not fully established.
It has been found that the culture medium used to cultivate stem cells usually contains cytokines that are several hundred times higher than adults. There are reports that it is highly effective and does not cause inflammation compared to the adipose stem cell-derived supernatant.
This culture medium rich in cytokines is called cytokine cocktail (stem cell culture supernatant).
Cytokines don't have to worry about becoming tumorous (cancerous).In addition, pulp-derived cytokine cocktail therapy is attracting attention as a regenerative medicine that is safer and easier than stem cell transplantation and can be expected to achieve the same level of therapeutic effect.
Regenerative medicine skin treatment
Deciduous dental pulp stem cell supernatant
Inject subcutaneously into skin
|Treatment time||About 10 minutes|
|Indication symptoms||Wrinkle improvement, skin tension, texture improvement, dullness improvement, acne scars, etc.|
|Treatment method||Direct injection or introduction with microneedles.|
|downtime||Please refrain from makeup only on the day.|
|pain||There is almost no pain because the anesthetic of the coating is used.|
|Treatment effect manifestation||It will be felt from the next day.|
Cytokines suppress skin aging and promote youthful skin regeneration.
This is a new treatment that can be performed in a short time without side effects.
Unlike conventional PRP therapy, there is an advantage that autologous blood collection is unnecessary and it can be performed quickly and easily.
Deciduous dental pulp stem cells and
Features of cytokine cocktail
Cytokine cocktail therapy is a regenerative therapy that activates stem cells in the brain by administering growth factors (cytokines) to promote self-repair.
|Treatment time||A few seconds (10 to 15 minutes on your back)|
|Number of treatments||1-10 times 1 cool every 2 weeks for basic treatment.|
|Pain after treatment||Report does not.|
|Treatment effect manifestation||Even if you can feel it from the next day though there are individual differences|
Perform injections and infusions.
Injection and infusion of deciduous dental pulp-derived cytokine cocktail (stem cell culture supernatant) using cytokines (proteins) released from stem cells.
This treatment, which uses cytokines responsible for the command lineage of each tissue, is expected to have the same therapeutic effect as stem cell transplantation treatment. Alone, the administration method is the nasal nose that allows the fastest drug transfer to the brain. Infusion is used as a combined treatment.
|Only the first medical examination fee||10,000 Yen(Tax not included)|
No re-examination fee is required
|Dental skin stem cell supernatant injection||120,000 Yen(Tax not included)|
|Deciduous pulp stem cell supernatant|
|120,000 Yen(Tax not included)|
(It becomes the content ingredient which added deciduous pulp stem cell supernatant to cocktail drip)
|Deciduous pulp stem cell supernatant|
Microneedle skin treatment
|150,000 Yen(Tax not included)|
* Treatment is free medical care (not covered by insurance).
Previously, we used adipose stem cell-derived supernatant for treatment.
We have used adipocytes-derived supernatant and cytokines for hair growth and hair growth treatment such as HARG therapy. In fat, adipocytes after liposuction are mostly used, and the risk of infectious diseases is not 100% denied, as with other biologics, and may cause an inflammatory response.
On the other hand, for dental pulp stem cells, donors and collection routes have been established and are superior to stem cells from other tissues in terms of safety, effectiveness, and anti-inflammatory effects.
PRP therapy is a plasma containing high-concentration platelets obtained by centrifuging collected blood, not a treatment that injects cytokines. Therefore, unlike stem cell therapy, it contains almost no growth factors or cytokines, and its cell activation effect is limited to some diseases such as sports.
In this hospital, combination therapy is also carried out, and a great therapeutic effect is obtained in the sports field and the beauty field.
This is the only medical institution in Japan that can receive combined treatment of PRP therapy and stem cell supernatant, and provides treatment for sports trauma of many world-renowned top athletes.
PRP therapy requires blood collection and requires time and effort.
Stem cell transplantation can cause inflammation and allergic reactions due to the proteins contained in the body, and the risk of side effects such as fever and fatigue.
On the other hand, treatment with stem cell culture supernatant is safe because it contains many growth factors and cytokines, and is expected to be as effective as stem cell transplantation.
The difference is whether you use cells or cytokines, which are therapeutic essences released from the cells.
It is an epoch-making treatment that can be done quickly and easily without burden on the body. Any method of administration is possible. (Introduction to the skin using eye drops, nose drops, drip, microneedle, fractional laser)
This is a next-generation treatment that solves the problems of regenerative treatment risks, complexity, and high costs.
|Stem cell therapy|
|1: There is a risk of tumor|
|2: Takes a long time|
|3: Uncertain therapeutic effect due to culture method|
|4: Expensive treatment costs|
|5: Safety issues such as pulmonary embolism|
|6: In principle, no nasal treatment is performed|
|Stem cell culture supernatant|
|1: No tumor formation|
|2: Treatment is completed in a short time|
|3: Stable formulation and stable effect|
|4: Cheap treatment costs compared to stem cell treatment|
|5: High safety|
|6: Can be treated with nasal nose, direct approach to the brain|
Introduction of the clinic
Director and Medical Doctor Nobuhiro Suetake
Directions and Parking
Insurance medical institution
Cosmetic surgery / dermatology / plastic surgery
Nishiki, Naka-ku, Nagoya, Aichi Prefecture 3-5-21
Nishiki HOTEI Building 2F
Closed day: Wednesday, irregular holidays
Medical treatment: Complete reservation system
Hours: 10: 00 ~ 19: 00
1 minute walk from Hisaya-Odori Station on Subway Sakuradori Line / Meijo Line
4-minute walk from Sakae Station on the Higashiyama Line