Reading Time: <1 minute Exosome infusion therapy may be effective, but there is currently no evidence. Many reagents are sold and administered by infusion at various medical institutions, but it is an experimental treatment without confirmation of its effectiveness, examination of the contents, or creation of a protocol. The reagent is administered under the responsibility of the doctor, and there is no guarantee of its safety or effectiveness. There are cosmetic surgery clinics that are profit-oriented and try to attract patients with flashy advertising, but it is unlikely that the doctors who administer it have any specialized knowledge. It is still moral and common sense for doctors to administer it carefully. There are risks, such as the possibility of promoting carcinogenesis and the oxidation of the body due to the administration of inflammatory cytokines. The exact same effect can be obtained with vagus nerve stimulation therapy. Unlike exosome infusion, this is a risk-free, easy, inexpensive, and evidence-based extremely important treatment that is performed all over the world. There are many papers on the subject, and its potential and effectiveness are expected to be effective for a wide range of diseases, including autism, depression, improving paralysis after cerebral infarction, dementia, improving concentration, Parkinson's disease, chronic rheumatoid arthritis, chronic fatigue syndrome, Crohn's disease, aftereffects of COVID-19 infection, and more. Medical institutions do not use it as a treatment because it is not profitable, but it is already widespread around the world as neuromodulation. Our hospital is working with multiple companies to develop the techniques and devices.