Reading Time: <1 minute As a director of the Japanese Society of Aesthetic Internal Medicine, I hope that my 33 years of experience as a clinician in aesthetic medicine and 25 years of experience as a researcher into the autonomic and vagus nerves will be of use to you. As exosome infusion and stem cell culture supernatant infusion are hot topics, I will work to build evidence and promote the next generation of healthcare, vagus nerve activation therapy, which will go beyond exosome infusion and stem cell culture supernatant infusion.