Reading Time: <1 minutehttps://news.yahoo.co.jp/pickup/6480314 Shocking news has been reported. Death caused by stem cell culture supernatant. Although the details have not been reported, it seems that several people died. There is also information that the cause was not exosomes, but sepsis, but the truth of this is still unknown. If it was sepsis, it would be a major incident in which the medical institution would be suspected of serious professional negligence resulting in death. In the past, a medical institution in Mie Prefecture has had health damage and deaths from sepsis in patients who were administered unsanitary infusions that had been prepared in advance, and this was reported by many media outlets (Chunichi Shimbun and various television stations). This time, there does not seem to have been any television or newspaper coverage. From the perspective of teaching risk management at Juntendo University Graduate School of Medicine, it is assumed that this incident was caused by problems with the management system and the laziness of doctors and medical institution staff who lacked the awareness that it was a reagent and not yet an evidence-based treatment. Even if there was no problem with the stem cell culture supernatant and exosome reagents themselves, this incident has extremely negatively affected the impression of stem cell culture supernatant and exosome reagent administration treatment. There seems to be criticism from exosome researchers. Exaggerated advertising at some cosmetic surgery clinics, and shady regenerative medicine businesses run by cosmetic surgeons and investors who prioritize profits. I hope that the public's view of stem cell culture supernatant and exosome therapy, which have great potential, will not be negatively influenced.