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Currently, exosome infusion is being carried out in many beauty clinics, with flashy advertising such as rejuvenation and effectiveness against cancer. At present, there is no evidence whatsoever, and no detailed disclosure of the ingredients has been made. The reality is that unscrupulous businesses are using exosomes to sell to beauty clinics. In other words, the Ministry of Health, Labor and Welfare has begun to take action against the reality that reagents (not approved as drugs by the Ministry of Health, Labor and Welfare) whose effectiveness, safety and ingredients are not well understood are being used for beauty, anti-aging and cancer treatment by false and exaggerated advertising. The Japan Society of Aesthetic Internal Medicine, of which I am a director, is also concerned about the abnormal profit-first spread of exosome therapy without evidence. Moreover, not only do the doctors who perform this exosome infusion therapy have no knowledge of exosomes, but there are also facilities where nurses only perform infusions without doctors present, and only attract customers. Depending on how the exosome reagent is stored, bacteria can grow and become contaminated. If it is administered by infusion, there is a risk of sepsis. Furthermore, there are beauty clinics that administer it to athletes to improve their performance. Despite the fact that cosmetic medicine is supposed to be wonderful, the actions of some unscrupulous medical institutions are unforgivable and cannot be evaluated as outrageous fraudulent medical treatment. Please do not be fooled by flashy, unfounded advertising claims such as "effective against cancer," "good for beauty," and "great anti-aging effects." Athletes should never receive exosome infusions with unknown ingredients, which can be considered a form of doping.